Process for preparing live varicella vaccines
AssigneeThe Research Foundation for Microbial Diseases of Osaka University
InventorTakashi Kubo
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Abstract
A process for the attenuation of varicella virus comprising passaging varicella virus in a guinea pig primary embryonic tissue cell. Live avirulent varicella vaccines are also advantageously prepared by continuing the passaging until the virus is sufficiently attenuated for use as a live avirulent varicella vaccine.
Claims4
A process for the attenuation of varicella virus comprising passaging the varicella virus in a guinea pig primary embryonic tissue cell at a temperature of 32.degree. - 37.degree. C until the virus is adequately attenuated.
A process for the preparation of a live avirulent varicella vaccine from virulent varicella virus by passaging in a tissue culture technique, characterized in that a guinea pig primary embryonic tissue cell is employed as a culture host at a temperature of 32-37.degree. C, passaging is continued until the virus is adequately attenuated, and the virus is thereafter separated from the culture host, such virus being suitable for administration as a vaccine.
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