Phenyl- and benzylphosphonate esters
AssigneeNelson Research & Development Company
InventorsVithal J. Rajadhyaksha, James V. Peck, Julia J. Chouw
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Abstract
Compounds having the structural formula ##SPC1## Wherein X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is H, alkyl, dialkylaminoethyl, aryl, aralkyl or aryl and aralkyl substituted with one or more R, and R is H, lower alkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2, OH, CN, COOR.sub.1, ##EQU1## NHCOR.sub.1, NR.sub.1 R.sub.2 or ##EQU2## where R.sub.1 and R.sub.2 are each selected from the group consisting of H and lower alkyl; R, R.sub.1 and R.sub.2 being the same or different, T is 0 or 1 and n is 0-5; and pharmaceutically acceptable salts thereof.
Claims7
Phenyl- and benzylphosphonate esters having the structural formula ##SPC19##
- wherein X is an alkyl or alkenyl chain having 2-8 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is selected from the group consisting of H, an alkyl group having 1-12 carbon atoms, phenyl, benzyl and phenyl or benzyl substituted with one or more R;
- and R is selected from the group consisting of H, loweralkyl, lower alkoxy, halogen, CF.sub.3, NO.sub.2, OH, CN, COOR.sub.1, CONR.sub.1 R.sub.2, NHCOR.sub.1, NR.sub.1 R.sub.2, and CH.sub.2 NR.sub.1 R.sub.2 R.sub.1 and R.sub.2 are each selected from the group consisting of H and lower alkyl, R, R.sub.1 and R.sub.2 being the same or different, T is 0 or 1, and n is 0-5;
- and pharmaceutically acceptable salts thereof.
Benzyl phosphonate esters having the structural formula ##SPC21##
- wherein X is an alkyl or alkenyl chain having 3-5 carbon atoms, one of which carbon atoms may be in the form of a carbonyl group, Y is selected from the group consisting of H, ##SPC22##
- R is selected from the group consisting of H, lower alkyl, lower alkoxy and halogen;
- n is 0-3 and pharmaceutically acceptable salts thereof.
Benzylphosphonates having the structural formula ##SPC23##
- where R is selected from the group consisting of an H or halogen;
- and pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.