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US 3,984,440 AGranted
Polyene compounds
AssigneeHoffmann-La Roche Inc.
InventorsWerner Bollag, Rudolf Ruegg, Gottlieb Ryser
Life of this patent
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Abstract
Novel 9-substituted phenyl-3,7-dimethyl-nona-2,4,6,8-tetraenoic acid, -tetraenal or -tetraenol derivatives are described. The subject compounds are useful in the treatment of neoplasias, certain dermatoses and inflammatory and allergic dermatological conditions.
Claims3
A compound having all trans configuration selected from compounds represented by the formula ##SPC6##
- wherein one adjacent pair of R.sub.1 through R.sub.5 is a oxytrimethylene or 3-oxypropenylene group which may be substituted with one or two lower alkyl groups and the remaining members of R.sub.1 through R.sub.5 each are selected from the group consisting of hydrogen, lower alkyl and lower alkoxy, at least one of said remaining members of R.sub.1 through R.sub.5 being other than hydrogen and R.sub.6 is selected from the group consisting of carboxyl and lower alkoxycarbonyl.
Dependencies are inferred from the claim text.