Vaccines, the process for preparing the same and the applications thereof
AssigneeAgence Nationale de Valorisation de la Recherche (ANVAR)
InventorEdgar Hans Relyveld
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Abstract
This invention relates to a process for preparing vaccines, which consists in bringing into contact a toxic product with glutaraldehyde at a concentration and for a duration just sufficient to detoxify or inactivate said toxic product, and in stopping the glutaraldehyde-antigen reaction as soon as said inactivation stage is reached by physical and/or chemical means. The thus obtained inactivate product remaining antigenic and retaining its immunizing power, is usable as a vaccine for the preventive treatment of human and animals against infections caused for example by microbial or venomous toxins.
Claims27
A process for preparing a bacterial toxin comprising the steps of:
- a. reacting a bacterial toxin with glutaraldehyde of a concentration ranging from about 0.00131 M to about 0.0526 M and for a duration just sufficient for almost complete detoxification within 1 hour with complete detoxification within 3 hours, said detoxification being equivalent to formaldehyde detoxification requiring a period of not less than 2 weeks, to detoxify and inactivate said toxin,
- b. stopping the reaction as soon as said inactivation stage is reached, whereby an inactivated product is obtained which is usable as a bacterial toxin while remaining antigenic and retaining its immunizing power.
Dependencies are inferred from the claim text.