Coated adsorbent materials
AssigneeUniversity of Strathclyde
InventorsJames McNiven Courtney, Thomas Gilchrist, Eric Hutton Dunlop
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Abstract
An adsorbent material intended particularly for use in extracorporeal haemodialysis, is described which is composed of granules of an adsorbent which are coated with a biocompatible polymeric membrane which is semipermeable to the solutes selected for removal. The polymer is a copolymer containing carboxyl and amino groups. In use, solutes pass selectively through the membrane and are trapped by adsorption in the adsorbent thereby preventing or at least reducing the reverse process. To improve biocompatibility the product may be further coated with a plasma protein.
Claims8
A solute-adsorptive material composed of granules of an adsorbent capable of binding the solute and on the adsorbent granules of polymeric membraneous coating which is semi-permeable to selected solute or solutes, the polymeric coating being a copolymer of a first comonomer, and a second comonomer, the first comonomer being selected from the group consisting of acrylic acid, methacylic acid, itaconic acid, acrylamide, hydroxyacrylamide, vinyl pyrrolidone, dimethylaminoethyl acrylate, diethylaminoethyl acrylate, dimethylaminoethyl methacrylate, diethylaminoethyl methacrylate and hydroxyethyl methacrylate and the second comonomer being selected from the group consisting of acrylonitrile, methacrylonitrile, 2-vinylpyridine, 2-methyl-5-vinylpyridine;
- styrene and the C.sub.1 to C.sub.8 alkyl esters and the tert-butylaminoethyl and hydroxypropyl esters of acrylic, methacrylic and itaconic acids.
A method of preparing the solute-adsorptive material comprising treating a granular or particulate adsorbent with a solution of a copolymer in a solvent therefore, and removing the solvent by evaporation to form a semi-permeable membraneous coating on the said absorbent;
- the said copolymer comprising a copolymer of a first comonomer and a second comonomer wherein the first monomer is selected from the group consisting of acrylic acid, methacrylic acid, itaconic acid, acrylamide, hydroxyacrylamide, vinyl pyrrolidone, dimethylaminoethyl acrylate, diethylaminoethyl acrylate, dimethylaminoethyl methacrylate, diethylaminoethyl methacrylate and hydroxyethyl methacrylate and the second monomer is selected from the group consisting of esters of itaconic acid, acrylonitrile methacrylonitrile, 2-vinyl pyridine, 2-methyl-5vinyl pyridine and styrene, the said esters being selected from the group consisting of the methyl, ethyl, propyl, n-butyl, n-amyl, n-hexyl, n-heptyl, n-octyl, isobutyl, sec-butyl, iso-amyl, t-butylaminoethyl and hydroxypropyl esters.
Dependencies are inferred from the claim text.