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US 3,979,383 AGranted
Purification process for 7-aminocephalosporins
AssigneeEli Lilly and Company
InventorGene M. Wild
Life of this patent
Estimating the term…
Abstract
Cephalosporin nucleus compounds represented by the formula: ##SPC1## Wherein R is for example, acetoxy or a 1-(lower alkyl)-1H-tetrazole-5-yl, a 5-(lower alkyl)-1,3,4-thiadiazole-2-yl or a 5-(lower alkyl)-1,3,4-oxadiazole-2-yl group are purified via chromatography over the hydrophilic polyacrylic matrixed quaternary ammonium anionic exchange resin, Amberlite IRA-458.
Claims5
The process for purifying a cephalosporin nucleus compound of the formula ##SPC4##
- wherein R is a heterocyclic ring selected from the group consisting of ##SPC5##
- wherein R' is C.sub.1 -C.sub.4 alkyl, which comprises adsorbing said nucleus from an aqueous solution thereof at a pH between 6.5 and 8.5 on the polyacrylic quaternary methylammoniun anion exchange resin Amberlite IRA 458;
- eluting said resin with phosphate buffer at a pH between 7.5 and 9.0 acidifying the eluate to a pH of between 3.5 and 5.5;
- and separating said nucleus in a purified form from said acidified eluate.
1 more element
Dependencies are inferred from the claim text.