Piperazine diones
AssigneeJohn Wyeth & Brother Limited
InventorAdrian Charles Ward Curran
Life of this patent
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Abstract
This invention relates to piperazine diones having the formula: ##SPC1## Wherein R represents a phenyl lower alkyl radical in which the phenyl portion may be substituted by halogen, lower alkyl or lower alkoxy; A represents a straight or branched chain lower alkylene radical; R.sup.1 represents hydrogen or lower alkyl; and R.sup.2 and R.sup.3 independently represent hydrogen or alkyl of 1 to 3 carbon atoms, which possess anti-ulcer activity.
Claims8
A compound having the formula:
- ##SPC5##
- wherein R represents a benzyl, phenethyl, or 3-phenyl propyl group in which the phenyl portion may be mono-substituted by fluorine, chlorine, bromine, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, or butoxy;
- A represents a methylene, ethylene, propylene, or butylene group;
- R.sup.1 represents hydrogen, methyl, ethyl, n-propyl, isopropyl or n-butyl;
- and R.sup.2 and R.sup.3 independently represent hydrogen, methyl, ethyl, or n-propyl.
A method of treating gastric ulcers in an effected host which comprises administering to said host an effective amount of a compound having the formula:
- ##SPC6##
- wherein R represents a benzyl, phenethyl, or 3-phenyl propyl group in which the phenyl portion may be mono-substituted by fluorine, chlorine, bromine, methyl, ethyl, propyl, butyl, methoxy, ethoxy, propoxy, or butoxy;
- A represents a methylene, ethylene, propylene, or butylene group;
- R.sup.1 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, or n-butyl;
- and R.sup.2 and R.sup.3 independently represent hydrogen, methyl, ethyl, or n-propyl.
Dependencies are inferred from the claim text.