Steffimycinone, 7-deoxysteffimycinone and derivatives
AssigneeThe Upjohn Company
InventorRobert C. Kelly
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Abstract
Antibiotic steffimycinone (U-25,055), produced by acid hydrolysis or methanolysis of antibiotic steffimycin (U-20,661), or steffimycin B, and 7-deoxysteffimycinone (U-25,920) produced by hydrogenolysis of steffimycin or steffimycin B (U-40,615). Steffimycinone is active against various microorganisms, for example, Bacillus subtilis, Mycobacterium avium and Bacillus cereus; 7-deoxysteffimycinone is active against Sarcina lutea and Mycobacterium avium. Thus, these antibiotics can be used to inhibit the growth of the above microorganisms in various environments.
Claims4
Steffimycinone, a compound having the following structure:
- ##SPC4##
- and non-toxic alkali and alkaline earth metal salts thereof.
7-Deoxysteffimycinone, a compound having the following structure:
- ##SPC5##
- and non-toxic alkali and alkaline earth metal salts thereof.
4,6,7-Tri-O-acylates of steffimycinone wherein said acyl group consists of hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive;
- halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
4,6-Di-O-acylates of 7-deoxysteffimycinone wherein said acyl group consists of hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive;
- halo-, nitro-, hydroxy-, amino-, cyano-, thiocyano-, and lower alkoxy-substituted hydrocarbon carboxylic acid acyl of from 2 to 18 carbon atoms, inclusive.
Dependencies are inferred from the claim text.