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US 3,975,235 AGranted
Process for the production of cephamycin type antibiotic substances
AssigneeMeiji Seika Kaisha, Ltd.
InventorsTomizo Niwa, Hitoshi Goi, Takashi Shomura, Yasuaki Ogawa, Shigeharu Inouye, Kazuo Saito, deceased, Taro Niida
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Abstract
Novel 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-cephem-4-carbo xylic acid derivatives. Such derivatives are prepared by subjecting cephamycin type compounds to the action of esterase enzyme of mold fungi.
Claims6
A process for the production of 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-cephem-4-carbo xylic acid or its N-substituted derivative represented by the following formula ##SPC3##
- wherein R.sub.1 represents hydrogen, a lower acyl group, and an arylacyl group, a lower alkoxycarbonyl group or an arylalkoxycarbonyl group characterized in that a cephamycin type compound of the following formula:
- ##SPC4##
- wherein R.sub.1 is defined as above and R.sub.2 represents hydrogen, a sulfo group, a lowr acyl group or an arylalkoxycarbonyl group, is subjected to the action of an esterase enzyme capable of hydrolyzing an ester bond of said compound (I).
Dependencies are inferred from the claim text.