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US 3,974,289 AGranted
Coumarin derivatives for the treatment of allergies
AssigneeBeecham Group Limited
InventorsDerek Richard Buckle, Harry Smith, Barrie Christian Charles Cantello
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions for the treatment of allergies are produced using coumarin derivatives as the active agent. Certain of these compounds and their salts are novel.
Claims58
A pharmaceutical composition in a form suitable for oral, parenteral or insufflation administration to humans which comprises a compound of the formula (I) ##SPC6##
- or a pharmaceutically acceptable non-toxic salt thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, phenoxy, benzyloxy, phenyl, benzyl, pyridyl, hydroxy, nitro, or halogen or any two of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4 taken together with the carbon atoms to which they are joined form a phenyl or 1,2-cyclohexenylene ring, in an amount sufficient to be effective for the prophylaxis of asthma, hayfever, or rhinitis in combination with a pharmaceutically acceptable non-toxic inert
A method for the prophylaxis of asthma, hayfever and rhinitis in humans which comprises administering to a human in need thereof orally, parenterally or by insufflation a compound of the formula (I) ##SPC8##
- or a pharmaceutically acceptable non-toxic salt thereof, wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are each hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, phenoxy, benzyloxy, phenyl, benzyl, pyridyl, hydroxy, nitro, or halogen or any two of the groups R.sub.1, R.sub.2, R.sub.3 and R.sub.4 taken together with the carbon atoms to which they are joined form a phenyl or 1,2-cyclohexenylene ring, in an amount sufficient to be effective for the prophylaxis of asthma, hayfever or rhinitis, in combination with a pharmaceutically acceptable non-toxic
Dependencies are inferred from the claim text.