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US 3,973,608 AGranted
Microbial production of certain isoflavones
AssigneeZaidan Hojin Biseibutsu Kagaku Kenkyu Kai
InventorsHamao Umezawa, Tomio Takeuchi, Hideo Chimura, Tsutomu Sawa, Masa Hamada
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Abstract
This invention relates to the novel compounds 3',5,7-trihydroxy-4',6-dimethoxy-isoflavone, 3',5,7-trihydroxy-4',8-dimethoxy-isoflavone and 3',7-dihydroxy-4',6,8-trimethoxy-isoflavone which are powerful inhibitors of catechol-O-methyl transferase (COMT) and to their production by fermentation of Actinomyces roseolus.
Claims6
The process for the production of the compound having the formula ##SPC9##
- which comprises cultivating a strain of Actinomyces roseolus having the characteristics of strain A.T.C.C. 31047 at a temperature of about 25.degree. to 35.degree.C. for at least two days under submerged aerobic conditions in an aqueous assimilable carbohydrate solution containing an assimilable nitrogenous nutrient until a substantial amount of said compound is produced in said solution and then recovering said compound.
The process for the production of the compound having the formula ##SPC10##
- which comprises cultivating a strain of Actinomyces roseolus having the characteristics of strain A.T.C.C. 31047 at a temperature of about 25.degree. to 35.degree.C. for at least two days under submerged aerobic conditions in an aqueous assimilable carbohydrate solution containing an assimilable nitrogenous nutrient until a substantial amount of said compound is produced in said solution and then recovering said compound.
The process for the production of the compound having the formula ##SPC11##
- which comprises cultivating a strain of Actinomyces roseolus having the characteristics of strain A.T.C.C. 31047 at a temperature of about 25.degree. to 35.degree.C. for at least two days under submerged aerobic conditions in an aqueous assimilable carbohydrate solution containing an assimilable nitrogenous nutrient until a substantial amount of said compound is produced in said solution and then recovering said compound.
Dependencies are inferred from the claim text.