Racemization of optically active amines
AssigneeSumitomo Chemical Company, Limited
InventorsTsuneyuki Nagase, Gohu Suzukamo, Yoshio Suzuki
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Abstract
A method for racemization of optically active amines which comprises contacting an optically active amine of the formula: ##EQU1## wherein C* is an asymmetric carbon atom, R.sub.1 is alkyl, aralkyl or aryl and R.sub.2 is aryl or alkoxycarbonyl, the aryl or aralkyl moiety bearing optionally one or more alkyl or alkoxy groups on the aromatic ring, provided that R.sub.1 and R.sub.2 are always different from each other, with an alkali metal catalyst selected from the group consisting of (1) an alkali metal deposited on a solid carrier, (2) an alkali metal dispersed in a liquid medium and (3) an alkali metal alloy at a temperature of from -10.degree. to 50.degree.C until a sufficient amount of the optically active amine is recemized.
Claims9
A method for racemization of optically active amines which comprises contacting an optically active amine of the formula:
- ##EQU3## wherein C* is an asymmetric carbon atom, R.sub.1 is alkyl, aralkyl or aryl C. R.sub.2 is aryl or alkoxycarbonyl, the aryl or aralkyl moiety being unsubstituted or being substituted with one or more alkyl or alkoxy groups on the aromatic ring, provided that R.sub.1 and R.sub.2 are always different from each other, with an alkali metal catalyst selected from the group consisting of (1) an alkali metal deposited on a solid carrier, (2) an alkali metal dispersed in a liquid medium and (3) an alkali metal alloy at a temperature of from -10.degree. to 50.degree.C
Dependencies are inferred from the claim text.