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US 3,970,518 AGranted
Magnetic separation of biological particles
AssigneeGeneral Electric Company
InventorIvar Giaever
Life of this patent
Estimating the term…
Abstract
Small magnetic particles coated with an antibody layer are used to provide large and widely-distributed surface area for sorting out and separating select viruses, bacteria and other cells from multi-cell, bacteria or virus populations.
Claims8
A method for the separation of a select population of cells, bacteria or viruses from a mixed population comprising the steps of:
- contacting a solution of said mixed population containing members of said select population with a plurality of small magnetic particles each of which is coated with a layer of antibodies to the select population bonded thereto,
- magnetically separating said magnetic particles from said solution, said magnetic particles having on surface area thereof members of said select population affixed as a complex to said layer of antibodies,
- contacting these coated magnetic particles with said members affixed thereto with a cleaving agent solution to detach said members of the select populaton from said antibody-coated magnetic particles and
- magnetically separating the antibody-coated magnetic particles from the cleaving agent solution now containing said members of the select population.
1 more element
Dependencies are inferred from the claim text.