Carrier-bound protein prepared by reacting the protein with an acylating or alkylating compound having a carrier-bonding group and reacting the product with a carrier
AssigneeBoehringer Mannheim GmbH
InventorsDieter Jaworek, Michael Nelbock-Hochstetter, Klaus Beaucamp, Hans Ulrich Bergmeyer, Karl-Heinz Botsch
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Abstract
Carrier-bound proteins are prepared by reacting a protein in aqueous solution with a coupling compound having at least one group capable of acylating or alkylating proteins and at least one additional group capable of producing a bond with a carrier material, and reacting the resulting product with a carrier material, optionally forming the carrier material in situ by polymerization of a monomer or monomer mixture in the presence of said product.
Claims17
Process for the preparation of a carrier-bound protein, which process comprises reacting a protein in aqueous solution with a compound containing at least one group capable of acylating or alkylating proteins, said group being selected from the class consisting of an ethyleneimine group, a halide group activated by unsaturation, an acid-halide group, an azide group, an acid anhydride group, an aldehyde group, and an oxazolone group;
- and at least one additional group capable of producing a bond with a carrier material, and reacting the reducing product with a carrier material.
Dependencies are inferred from the claim text.