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US 3,964,970 AGranted
Process for the preparation of L-car-bamyl-amino acids and of the corresponding L-amino acids
AssigneeSnam Progetti S.p.A.
InventorsDino Dinelli, Franco Morisi, Delio Zaccardelli
Life of this patent
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Abstract
A process for the preparation of only one of the two stereoisomer forms carbamyl amino acids is provided wherein certain heterocyclic compounds having an assymmetrical carbon, such as 5-substituted hydantoins, are hydrolyzed in the presence of certain enzymes, such as dihydropyrimidinase extracted from calf liver. In another embodiment of the invention, the corresponding amino acids are provided by hydrolyzing the carbamyl amino acids in the presence of these same enzymes.
Claims23
A process for the preparation of only one of the two stereoisomer forms of carbamylamino acids comprising:
- a. subjecting to hydrolysis a racemic mixture of compounds of the formula ##EQU4## wherein X is selected from the group consisting of CO, CS and O, R is selected from the group consisting of hydrogen and hydrocarbon radicals having up to 8 carbon atoms, R.sub.1 is the residue of an amino acid molecule wherefrom the ##EQU5## moiety has been removed, said hydrolysis being carried out in the presence of an enzyme which acts on the racemic mixture through a selective hydrolysis of only one of the optically active forms:
- b. separating the sole resultant carbamyl amino acid stereoisomer.
Dependencies are inferred from the claim text.