3-Halo-cephalosporins
AssigneeMeiji Seika Kaisha, Ltd.
InventorsMasao Koyama, Shigeo Seki
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Abstract
A novel ester of 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide, and a novel 7-acylamido-3-methyl-cepham-4-carboxylic acid derivative and a process for the preparation thereof which comprises reacting penicillin sulfoxide ester with the metal halide and decomposing the resultant in a reductive atmosphere.
Claims11
A compound of the formula:
- ##SPC8##
- wherein R.sup.1 represents benzyl or phenoxymethyl, R.sup.2 represents hydrogen, methyl, benzyl, p-nitrobenzyl or 2,2,2-trichloroethyl, and X is chlorine, bromine or iodine.
7-phenoxyacetoamido-3-chloro-3-methyl-cepham-4-carboxylic acid methylester.
7-phenoxyacetoamido-3-chloro-3-methyl-cepham-4-carboxylic acid benzylester.
7-phenoxyacetoamido-3-chloro-3-cepham-4-carboxylic acid p-nitrobenzylester.
7-phenoxyacetoamido-3-chloro-3-methyl-cepham-4-carboxylic acid 2,2,2-trichloroethylester.
7-phenoxyacetoamido-3-iodo-3-methyl-cepham-4-carboxylic acid methylester.
7-phenoxyacetoamido-3-iodo-3-methyl-cepham-4-carboxylic acid p-nitrobenzylester.
7-phenoxyacetoamido-3-bromo-3-methyl-cepham-4-carboxylic acid methylester.
7-phenylacetoamido-3-chloro-3-methyl-cepham-4-carboxylic acid methylester.
7-phenylacetoamido-3-iodo-3-methyl-cepham-4-carboxylic acid methylester.
7-phenoxyacetoamido-3-chloro-3-methyl-cepham-4-carboxylic acid.
Dependencies are inferred from the claim text.