Live brovine adenovirus vaccines, preparation thereof and method of vaccination using them
AssigneeRecherche et Industrie Therapeutiques (R.I.T.)
InventorsNathan Zygraich, Constant Huygelen
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Abstract
The invention relates to live virus vaccines containing temperature-sensitive mutant strains of bovine Adenovirus, the cut-off temperature of said mutant strain being comprised between 39.degree. and 40.degree. C. The invention also relates to the induction of said temperature-sensitive mutant strains and to a vaccination method by intranasal administration of the obtained vaccines.
Claims8
A polyvalent live intranasal bovine respiratory vaccine comprising (1) an intranasally effective dose of a temperature-sensitive nitrous acid mutant of a pathogenic bovine adenovirus, said mutant being protective against bovine adenovirus type 3 infection, having a cut-off temperature of from about 39.degree. to 40.degree.C, and being able to multiply in the upper respiratory tract of a bovine animal while having inhibited replication in the lower respiratory tract and internal organs of the body;
- (2) an intranasally effective dose of a vaccinal live temperature-sensitive mutant of a pathogenic infectious bovine rhinotracheitis virus;
- and (3) a pharmaceutical diluent.
A polyvalent live intranasal bovine respiratory vaccine comprising (1) an intranasally effective dose of a temperature-sensitive nitrous acid mutant of a pathogenic bovine adenovirus, said mutant being protective against bovine adenovirus type 3 infection, having a cut-off temperature of from about 39.degree. to 40.degree.C, and being able to multiply in the upper respiratory tract of a bovine animal while having inhibited replication in the lower respiratory tract and internal organs of the body;
- (2) an intranasally effective dose of a vaccinal live temperature-sensitive mutant of a pathogenic bovine parainfluenza 3 virus;
- and (3) a pharmaceutical diluent.
A polyvalent live intranasal bovine respiratory vaccine according to claim 17 comprising (1) an intranasally effective dose of a temperature-sensitive nitrous acid mutant of a pathogenic bovine adenovirus, said mutant being protective against bovine adenovirus type 3 infection, having a cut-off temperature of from about 39.degree. to 40.degree.C, and being able to multiply in the upper respiratory tract of a bovine animal while having inhibited replication in the lower respiratory tract and internal organs of the body;
- (2) an intranasally effective dose of a vaccinal live temperature-sensitive mutant of a pathogenic infectious bovine rhinotracheitis virus;
- (3) an intranasally effective dose of a vaccinal live temperature-sensitive mutant of a pathogenic bovine parainfluenza 3 virus;
- and (4) a pharmaceutical diluent.
Dependencies are inferred from the claim text.