Spray-drying technique for preparing agglomerated powders
AssigneeHoffmann-La Roche Inc.
InventorsMarco Alfred Cannalonga, Louis Vincent Czarecki
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Abstract
A novel spray-drying technique process, and the resulting composition, for preparing a high density, agglomerated vitamin-containing composition having improved tableting characteristics.
Claims10
In a process for preparing coated agglomerated powders suitable for direct compression tablets comprising:
- A. spraying into a spray dryer chamber droplets of a spray-dryable formulation selected from the group consisting of an aqueous vitamin slurry and an aqueous vitamin emulsion, to produce a spray-dried powder thereby, the improvement comprising:
- B. metering into said chamber, in a concentration of about 1-5% by weight, based on the weight of said spray-dried powder, a dry particulate absorbent having:
- a. a particle size of from about 2 microns to about 16 microns;
- b. an oil absorption capacity of from about 150 to about 400 pounds of oil per 100 pounds of absorbent;
- c. a surface area of from about 175 to about 360 square meters per gram;
- d. insolubility in cold water;
- e. resistance to wetting by water;
- f. a free-flowing property and
- g. ability to not develop static electricity
- said absorbent contacting said spray droplets in a semi-dry condition to coat said droplets and form a dry agglomerated powder thereof,
- wherein said absorbent minimizes the development of static electricity during step A and on the resulting dried agglomerated powder.
The process of claim 1 wherein said absorbent is a mixture comprising, in percents by weight based on the weight of said absorbent, from about 1% to about 15% of the absorbent as defined in claim 20 and from about 99% to about 85% of the spray dried formulation without absorbent.
In a process for preparing agglomerated Vitamin E powders for direct compression tabletting comprising
- A. spraying into a dryer chamber droplets of a spray-dryable Vitamin E aqueous emulsion formulation to produce a spraydried Vitamin E powder thereby,
- the improvement comprising
- B. metering into said chamber in a concentration of from about 1% to about 2% by weight, based on the weight of the spraydried powder, of a dry particulate absorbent consisting of a mixture of
- a. from about 4% to about 12% of a calcium silicate having:
- i. an average particle size of 3.4 microns,
- ii. an oil absorption capacity of 100-300 pounds of oil per 100 pounds of calcium silicate, and
- iii. a surface area of 175 square meters per gram and
- b. from about 96% to about 88% of a spray-dried Vitamin E composition, prepared without absorbent in the dryer chamber, having:
- i. a particle size range of from about 20 to about 30 microns,
- ii. from about 15% to about 20% of dl-.alpha.-tocopheryl acetate,
- iii. from about 80% to about 85% of hydrolyzed gelatin of O Bloom and a molecular weight of about 7,000 to about 11,000,
- iv. about 1% of sodium benzoate and
- v. about 0.7% of sorbic acid
- said absorbent contacting said spray droplets in a semi-dry condition to coat said droplets and form a dry agglomerated powder thereof,
- wherein said absorbent minimizes the development of static electricity during step A and on the resulting dried agglomerated powder.
Dependencies are inferred from the claim text.