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US 3,962,275 AGranted
7-Oxa steroids
AssigneeHoffmann-La Roche Inc.
InventorsRobert William Guthrie, Richard Wightman Kierstead, Ronald Andrew Lemahieu
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Abstract
7-Oxa steroids which may be substituted in the 3-position with a hydroxy or oxo group or in the 2-position with a hydroxymethylene group or in the 2- and 3-positions with a substituent that forms a 5-membered heterocyclic ring, useful as antigonadotropic agents and a method of preparing these 7-oxa steroids from 3-hydroxy .DELTA..sup.5 -steroids including intermediates in this process.
Claims2
A compound of the formula:
- ##SPC16##
- wherein R.sub.2 and R.sub.3 are taken togther to form a pyrazole ring;
- R.sub.18 is hydroxy or hydroxy esterified with a lower alkanoic acid or a halo lower alkanoic acid, with said alkanoic acid containing from 2 to 7 carbon atoms.
Dependencies are inferred from the claim text.