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AssigneeSchering Corporation
InventorsHanns Ahrens, Clemens Rufer, Helmut Biere, Eberhard Schroder, Wolfgang Losert, Olaf Loge, Ekkehard Schillinger
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1,2-Substituted biguanides of the formula ##EQU1## wherein R.sub.1 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; a cycloalkyl group of 3-6 carbon atoms; or an aryl or aralkyl group of the formula ##SPC1## With n being the integer 0, 1 or 2 and X being hydrogen or halogen; and R'.sub.1 is a hydrogen atom or a saturated or unsaturated, straight-chain or branched hydrocarbon group of 1-12 carbon atoms; or R.sub.1 and R'.sub.1 collectively with the nitrogen atom to which they are attached are a heterocyclic ring containing one or more hetero atoms; and R.sub.2 is saturated or unsaturated, straight-chain or branched hydrocarbon of 1-12 carbon atoms which is unsubstituted or substituted by one or more fluorine atoms; or cycloalkyl of 3-6 carbon atoms, alkoxyalkyl containing a total of 2-12 carbon atoms, or alkoxy of 1-6 atoms; mixtures thereof, and pharmaceutically acceptable acid addition salts thereof, are useful in the treatment of diabetes mellitus.
A substituted biguanide of the formula ##EQU8## wherein R.sub.1 is alkyl of 1-8 carbon atoms, R'.sub.1 is hydrogen or alkyl of 1-8 carbon atoms and R.sub.2 is alkoxyalkyl of 2-12 carbon atoms, and pharmaceutically acceptable acid addition salts thereof.
A substituted biguanide of the formula ##EQU9## wherein R.sub.1 is alkyl of 1-8 carbon atoms, R'.sub.1 is hydrogen or alkyl of 1-8 carbon atoms and R.sub.2 is fluorosubstituted alkyl of 1-12 carbon atoms and 1-8 fluorine atoms, and pharmaceutically acceptable acid addition salts thereof.
1-Ethyl-2-n-butylbiguanide and pharmaceutically acceptable acid addition salts thereof.
Dependencies are inferred from the claim text.