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AssigneeToyo Jozo Kabushiki Kaisha
InventorsMasataka Morishita, Yoshihito Inaba, Mitsuru Fukushima, Yoshinori Hattori, Sadami Kobari, Tetsuo Matsuda
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Encapsulated medicaments are prepared by dissolving a wall material for capsules in at least one organic solvent poorly miscible with water which has a boiling point of less than 100.degree.C., a vapor pressure higher than that of water and a dielectric constant of less than about 10, dissolving or dispersing in the resulting solution a medicament which is insoluble or slightly soluble in water, dispersing the resulting solution or dispersion to the form of fine drops in a liquid vehicle comprising an aqueous solution of a hydrophilic colloid or surface active agent, and then removing the organic solvent by evaporation.
A process for preparing encapsulated medicines, characterized by dissolving a gastric-soluble, enteric soluble or semipermeable hydrophobic wall material in at least one organic solvent immiscible with water which has a boiling point of not more than 100.degree.C., a vapor pressure higher than that of water and a dielectric constant of not more than 10, dissolving or dispersing in the resulting solution a water-insoluble or slightly water-soluble medicament, dispersing the resulting solution or dispersion to the form of fine drops into a vehicle consisting of a hydrophilic colloid or a surface active agent in water, and then evaporating the organic solvent.
A process according to clailm 1, wherein said medicament is dissolved in said resulting solution.
A process for preparing water repellent encapsulated medicines, which comprises dissolving a mixture of a polymer selected from the group consisting of cellulose acetate dibutylaminohydroxypropyl ether, polyvinyl acetal diethylamino acetate, 2-methyl-5-vinylpyridine methacrylate-methacrylic acid copolymer, hydroxypropyl methyl cellulose phthalate, ethyl cellulose, cellulose acetate, cellulose propionate, cellulose butyrate, cellulose valerate, cellulose acetate propionate, polyvinyl acetate, polyvinyl formal, polyvinyl butyral, ladder polymer of sesquiphenyl siloxane, polymethyl methacrylate, polycarbonate, polystyrene, polyester, cumarone-indene polymer, polybutadiene, ethylene-vinyl acetate copolymer and vinyl chloride-propylene-vinyl acetate copolymer with a non-toxic wax or a higher fatty acid or an ester thereof having a melting point of not less than 50.degree.C in at least one organic solvent immiscible with water which has a boiling point of not more than 100.degree.C, a vapor pressure higher than that of water and a dielectric constant of not more than 10, dissolving or dispersing in the resulting solution a medicament selected from the group consisting of kitasamycin, acetyl-kitasamycin, spiramycin, acetylspiramycin, estradiol, erythromycin, erythromycin ethyl succinate, cortisone acetate, hydrocortisone acetate, predomisolone acetate, diazepam, triacetyl oleandomycin, chloramphenicol palmitate, phenacetin, progesterone, testosterone propionate, hexobarbital, methyl testosteron, ampicillin trihydrate, chloramphenicol, chlorodiazepoxide, cyclobarbital, strychnine nitrate, dexamethazone, tetracycline, nalidixic acid, barbital, hydrocortisone, predonisolone, bromvalerylurea and folic acid, dispersing the resulting solution or dispersion in the form of fine drops into a vehicle consisting of a hydrophilic colloid or a surface active agent in water, and then evaporating the solvent.
Dependencies are inferred from the claim text.