Substituted 1,3-dihydrospiro(isobenzofuran)s

A compound of the formula ##SPC4##

• in which
• R is hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, trifluoromethyl, halogen, hydroxy, or methylenedioxy;
• R.sub.1 is hydrogen, alkyl of 1 to 6 carbon atoms, cycloalkylalkyl of 4 to 8 carbon atoms, alkenyl of 3 to 6 carbon atoms, phenylalkyl of the formula (CH.sub.2).sub.x --PhR, diphenylalkyl of the formula (CH.sub.2).sub.m --CH(PhR).sub.2, diphenylmethoxyalkyl of the formula --(CH.sub.2).sub.m --OCHPh.sub.2, alkanoyl of 2 to 6 carbon atoms, phenylalkanoyl of the formula --CO(CH.sub.2).sub.x --PhR, benzoyl of the formula --COPhR, benzoylalkyl of the formula --(CH.sub.2).sub.m --COPhR, phenylhydroxyalkyl of the formula --(CH.sub.2).sub.m CHOHPhR, alkoxycarbonyl of 2 to 6 carbon atoms, phenyloxycarbonyl, or cycloalkylcarbonyl of 4 to 8 carbon atoms;
• R.sub.2 is alkyl of 1 to 6 carbon atoms or phenyl of the formula PhR.sub.m ;
• Y is hydrogen, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, hydroxy or phenyl of the formula PhR;
• Ph is phenyl;
• m, n and n' are integers from 1 to 3, the sum of n and n' being from 3 to 5;
• and
• x is an integer from 1 to 4, and
• the optical antipodes and the pharmaceutically acceptable acid addition salts thereof.