Process for the conversion of penicillin S-oxide into a corresponding desatoxycephalosporin
AssigneeSociete Anonyme dite: CLIN-MIDY
InventorLeone Dall'Asta
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Abstract
A penicillin S-oxide is rearranged into the corresponding desacetoxycephalosporin compound by heating said penicillin S-oxide at a temperature of from 70 to 140.degree.C in the presence of a sulfoxide of formula R.sup.1 -SO-R.sup.2, preferably dimethyl sulfoxide, or a sulfonium or sulfoxonium salt of said sulfoxyde or a mixture of said sulfoxide and said sulfonium or sulfoxonium salt. The sulfoxide may act as reaction medium as well as reactant or an inert organic solvent may be used as a reaction medium.
Claims12
A process for converting a penicillin S-oxide selected from the group consisting of a 6-acylamido-penicillanic acid S-oxide and esters thereof, into the corresponding desacetoxycephalosporin, comprising:
- effecting said conversion by heating said penicillin S-oxide to a temperature of 70.degree. to 140.degree.C in the presence of an amount of dimethyl sulfoxide effective for converting said penicillin S-oxide to the corresponding desacetoxycephalosporin.
Dependencies are inferred from the claim text.