Crosslinked, porous, polyacrylate beads
AssigneeCalifornia Institute of Technology
InventorsAlan Rembaum, Shiao-Ping Siao Yen, William J. Dreyer
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Abstract
Uniformly-shaped, porous, round beads are prepared by the co-polymerization of an acrylic monomer and a cross-linking agent in the presence of 0.05 to 5% by weight of an aqueous soluble polymer such as polyethylene oxide. Cross-linking proceeds at high temperature above about 50.degree.C or at a lower temperature with irradiation. Beads of even shape and even size distribution of less than 2 micron diameter are formed. The beads will find use as adsorbents in chromatography and as markers for studies of cell surface receptors.
Claims8
A composition consisting essentially of uniformly shaped, hydrophilic, swellable, porous, round beads, at least 80% having a uniform diameter from less than to 2 microns and being the cross-linked polymer of an acrylic monomer containing an hydroxy or amino group and of the formula:
- ##EQU3## where R.sup.1 is hydrogen or lower alkyl of 1-8 carbon atoms, R.sup.2 is alkylene of 1-12 carbon atoms, Z is OH or ##EQU4##
- where R.sup.3 or R.sup.4 are H, lower alkyl or lower alkoxy, and 0. 1 to 30 weight percent of a liquid diene or triene cross-linking agent.
Dependencies are inferred from the claim text.