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US 3,954,726 AGranted
Double salts of S-adenosil-L-methionine
AssigneeBioResearch Inc.
InventorAlberto Fiecchi
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Abstract
New double salts extremely stable of S-Adenosil-L-methionine with sulphuric acid and p.toluensulphonic acid of the formula SAM.sup.+.HSO.sub.4 .sup.-.H.sub.2 SO.sub.4.2CH.sub.3 C.sub.6 H.sub.4 SO.sub.3 H and SAM.sup.+.HSO.sub.4 .sup.-.H.sub.2 SO.sub.4.CH.sub.3 C.sub.6 H.sub.4 SO.sub.3 H, process for the preparation thereof and therapeutic compositions containing them.
Claims13
Double salts of S-adenosil-L-methionine (SAM) with sulphuric acid and p-toluenesulphonic acid.
Process for preparing double salts of S-adenosil-L-methionine (SAM) with sulphuric acid and p-toluensulphonic acid in which
- a. a concentrated solution of SAM is prepared;
- b. the SAM present in the solution is precipitated by acidifying with a solution of picrolonic acid;
- c. the SAM picrolonate is dissolved in a mixture consisting of equal parts by volume of an aqueous solution of equal normalities of p-toluenesulphonic acid and sulphuric acid, and an organic solvent partially miscible with water;
- d. the SAM salt is precipitated from the aqueous layer by a ketone or alcohol based solvent totally soluble in water;
- e. the precipitated salt is dissolved in a solution of p-toluenesulphonic acid in methanol;
- f. the double salt of SAM with sulphuric acid and p-toluenesulphonic acid is precipitated by a suitable organic solvent.
3 more elements
Dependencies are inferred from the claim text.