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AssigneesMassachusetts General Hospital, American Hospital Supply Corporation
InventorsJosef E. Fischer, Norman N. Yoshimura, Thomas L. Westman, Fred H. Deindoerfer
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Amino acid formulations for administration to human patients with liver disease comprise mixtures of essential amino acids combined in novel relative proportions, and preferably also include non-essential amino acids. In particular, the combined molar proportions of isoleucine, leucine, and valine are from 40 to 300 times the molar proportion of tryptophan and from 15 to 135 times the molar proportion of phenylalanine, or phenylalanine and tyrosine. The formulations may be adapted for either intravenous or oral administration, but the preferred method of administration is by hyperalimentation infusion. The formulations and method can be utilized to provide nutritional support for liver diseased patients while reducing the incidence and severity of hepatic encephalopathy, and/or as primary therapy for treatment of hepatic encephalopathy.
An amino acid formulation for administration to human patients with liver disease, comprising a mixture of the following essential and nonessential amino acids combined in proportions defined by the following interrelated molar ranges:
An intravenous infusion solution of amino acids for administration to human patients with liver disease, consisting essentially of a sterile aqueous solution of the following essential and nonessential amino acids in the following moles per liter of solution concentrations:
An amino acid preparation for oral administration to human patients with liver disease containing carbohydrate and/or fat nutrients together with a mixture of the following essential and nonessential amino acids combined in proportions defined by the following interrelated molar ranges:
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