Pharmacologically active thiourea and urea compounds

A compound of the formula:

• ##SPC12##
• wherein A is such that there is formed together with the carbon atom shown an unsaturated heterocyclic nucleus, said unsaturated heterocyclic neucleus being an imidazle or pyrazole ring;
• X.sub.1 is hydrogen, lower alkyl, hydroxyl, trifluoromethyl, benzyl, halogen, amino or ##EQU6## X.sub.2 is hydrogen or when X.sub.1 is lower alkyl, lower alkyl or halogen;
• k is 0 to 2 and m is 2 or 3, provided that the sum of k and m is 3 or 4;
• Y is oxygen, sulphur or NH;
• E is oxygen or sulphur;
• and R.sub.1 is hydrogen, lower alkyl, benzoyl or di-lower alkylamino-lower alkyl or a pharmaceutically acceptable addition salt thereof with the proviso that X.sub.1 is ##EQU7## only when Y and E are sulphur and R.sub.1 is methyl and with the proviso that when X1 is other than hydrogen or lower alkyl and X.sub.2 is other than hydrogen, X.sub.1 and X.sub.2 are attached at carbon atoms.