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US 3,948,971 AGranted
N-protected-.alpha.-amino acid compounds
AssigneeMerck & Co., Inc.
InventorsDaniel F. Veber, Stephen F. Brady
Life of this patent
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Abstract
Novel N-protected-.alpha.-amino acid compounds are disclosed in which the amino functionality is protected by a 1-methylcyclobutyloxycarbonyl or 1-methylcyclohexyloxycarbonyl. Processes for the synthesis of amino acids containing these protecting groups and the use of these novel amino acid compounds in the preparation of peptides are also disclosed.
Claims12
A compound of the formula:
- ##EQU2## wherein X is selected from the group consisting of 1-methylcyclobutyloxycarbonyl and 1-methylcyclohexyloxycarbonyl;
- R' is hydrogen;
- R is hydrogen, loweralkyl, or substituted loweralkyl wherein the substituent is selected from the group consisting of hydroxy, amino, carboxy, benzyl and hydroxybenzyl;
- and R" is hydrogen, benzyl or loweralkyl.
1 more element
The compound N-(1-methylcyclobutyloxycarbonyl) phenylalanine.
The compound N-(1-methylcyclohexyloxycarbonyl) phenylalanine.
Dependencies are inferred from the claim text.