Pharmaceutically useful bis-amine derivatives
AssigneeRichardson-Merrell Inc.
InventorIrving Shemano
Life of this patent
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Abstract
Compounds of the following general structure are useful in treating conditions of delayed hypersensitivity: ##EQU1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, carbazole, N-(lower) alkyl carbazole or anthraquinone; Y represents carbonyl, divalent sulfur or oxygen; with the proviso that when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone; A represents a straight or branched alkylene chain of from 1 to 6 carbon atoms; and each of R.sup.1 and R.sup.2 represents hydrogen, lower alkyl of from 1 to 4 carbon atoms, or alkenyl of from 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position; and pharmaceutically useful acid addition salts thereof.
Claims13
A method of treating conditions of delayed hypersensitivity which comprises administering to a patient in need thereof a compound selected from the formula ##EQU12## wherein [W] is an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, or anthraquinone;
- Y is selected from carbonyl, divalent sulfur, or oxygen with the proviso that when Y is carbonyl, [W] is other than fluoren-9-ol or anthraquinone;
- A is selected from a straight or branched alkylene chain of from 1 to 6 carbon atoms;
- and each of R.sup.1 and R.sup.2 is selected from hydrogen, straight or branched lower alkyl of from 1 to 4 carbon atoms, or alkenyl of 3 to 6 carbon atoms, having the vinyl unsaturation in other than the 1-position;
- and pharmaceutically acceptable acid addition salts thereof, in an amount effective to suppress delayed hypersensitivity.
Dependencies are inferred from the claim text.