Analgesics obtained by reacting a primary amine and an aldehyde
AssigneeSociete Anonyme Cortial S. A.
InventorGeorges Negrevergne
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AssigneeSociete Anonyme Cortial S. A.
InventorGeorges Negrevergne
Estimating the term…
Products having analgesic and antipyretic activity are provided having the formula: R -- Z -- R' in which each of R and R', which may be the same or different, represents a phenyl or pyridyl radical which is optionally substituted by at least one substituent selected from a halogen atom, --NO.sub.2, --CONH.sub.2 --, --OC.sub.2 H.sub.5, OCH.sub.3, --CH.sub.3, --COOC.sub.2 H.sub.5, --COOCH.sub.3, --COOH and --OCH.sub.2 --COOH radical; Z represents a radical selected from --CH=N-- and >CH--NH-- in which the radical >CH-- of said amino group forms part of a heterocyclic structure of the formula: ##EQU1## in which the two carbon atoms connected by a double bond form part of the radical R or R'. Specific compounds include 2-(2'-carboxamido-anilino)-o-phthalide and 2-(2' or 4'-ethoxy-anilino)-o-phthalide.
A pharmaceutical composition having analgesic, anti-inflammatory, and anti-pyretic activity which comprises, as the active ingredient, an analgesic, anti-inflammatory and anti-pyretic effective amount of at least one compound selected from the group consisting of compounds of the formula R--Z--R', in which each of R and R', which may be the same or different, represents a phenyl radical which is optionally substituted by at least one substituent selected from a halogen atom, --OC.sub.2 H.sub.5, --OCH.sub.3, --CH.sub.3, --COOC.sub.2 H.sub.5, --COOCH.sub.3, and --COOH radical;
A pharmaceutical composition having an analgesic, anti-inflammatory, and anti-pyretic activity which comprises, as the active ingredient, an analgesic, anti-inflammatory, and anti-pyretic effective amount of at least one compound selected from the group consisting of 2-(2'-carboxamido-anilino)-o-phthalide;
Dependencies are inferred from the claim text.