Omega-[4-(3"-indolyl)-piperidino]-alkyl-arylketones as nevroleptics
AssigneeRoussel Uclaf
InventorsPierre Henri Derible, Jean-Paul Lavaux
Life of this patent
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Abstract
Novel [4'-(3"-indolyl)-piperidino]-alkyl-arylketones of the formula ##SPC1## Wherein R is selected from the group consisting of hydrogen and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, n is 2 or 3 and X is selected from the group consisting of hydrogen, fluorine, chlorine and bromine and their non-toxic, pharmaceutically acceptable acid addition salts having central nervous system depressant activity.
Claims12
A novel neuroleptic composition comprising an effective amount of a compound of the formula ##SPC9##
- wherein R is selected from the group consisting of hydrogen and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, n is 2 or 3 and X is selected from the group consisting of hydrogen, fluorine, chlorine and bromine or a non-toxic, pharmaceutically acceptable acid addition salt thereof and a pharmaceutical carrier.
A method of depressing the central nervous system of a warm-blooded animal comprising administering to a warm-blooded animal an amount of a compound of the formula ##SPC10##
- wherein R is selected from the group consisting of hydrogen and alkoxy of 1 to 5 carbon atoms, R.sub.1 and R.sub.2 are individually selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, n is 2 or 3 and X is selected from the group consisting of hydrogen, fluorine, chlorine and bromine or a non-toxic, pharmaceutically acceptable acid addition salt thereof sufficient to depress the central nervous system.
Dependencies are inferred from the claim text.