Process for preparing the releasing hormone of luteinizing hormone (LH) and of follicle stimulating hormone (FSH), salts and compositions thereof, and intermediates therefor
AssigneeAmerican Home Products Corporation
InventorsHans U. Immer, Verner R. Nelson, Manfred K. Gotz
Life of this patent
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Abstract
A process for preparing the LH- and FSH-releasing hormone of the formula I h--pyr--His--Trp--Ser--Tyr--Gly--Leu--Arg--Pro--Gly--NH.sub.2 which is isolated as the hydrochloride salt and optionally converted to other pharmaceutically acceptable salts or to pharmaceutically acceptable metal complexes.
Claims2
A diagnostic method for distinguishing between hypothalmic and pituitary malfunctions or lesions in humans which comprises administering systemically to a human suspected of such malfunction from about 1 to 100 micrograms per kilogram of body weight of 5-Oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosylglycyl-L-leucyl-L- arginyl-L-prolylglycinamide or a pharmaceutically acceptable salt thereof, and detecting the rise in the level of serum leutenizing hormone.
Dependencies are inferred from the claim text.