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US 3,947,472 AGranted
Naphthyl acetaldehyde derivatives
AssigneeSyntex Corporation
InventorsJohn H. Fried, Ian T. Harrison
Life of this patent
Estimating the term…
Abstract
2-(2'-Naphthyl) acetaldehyde derivatives optionally substituted at the 2 position and/or positions C-1',4',5',7' or 8'; and/or position C-6' or positions C-5' and 7' exhibit anti-inflammatory, analgesic, antipyretic and anti-pruritic activity.
Claims9
A compound selected from the group represented by the formula:
- ##SPC5##
- wherein R is -CHR.sup.1 R.sup.2 ;
- R.sup.1 and R.sup.2 taken together are 3-hydroxypropylene-1,2-dioxy,-OCHR.sup. 4 -CHR.sup.5 O- or -OCHR.sub.6 -CR.sup.4 R.sup.5 -CHR.sub.6 O-, each of R.sup.4 and R.sup.5, independently of each other is hydrogen, alkyl having up to six carbon atoms, cycloalkyl having three to seven carbon atoms, cycloalkylmethyl having four to eight carbon atoms, 2-cycloalkylethyl having five to nine carbon atoms, benzyl or phenyl, said benzyl or phenyl being optionally substituted with one to two methyl, ethyl, isopropyl, methoxy, hydroxy, or chloro groups, or up to three fluoro groups;
- and R.sub.6 is hydrogen, methyl, ethyl or propyl;
- one of R.sup.6 and R.sup.7 is hydrogen, the other is hydrogen, methyl, ethyl, or difluoromethyl;
- or R.sup.6 and R.sup.7 taken together are methylene, halomethylene, or ethylene;
- and R.sup.9 is lower alkoxy.
4 more elements
Dependencies are inferred from the claim text.