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US 3,947,470 AGranted
Substituted benzofurans and benzothiophenes
AssigneeSmithKline Corporation
InventorsL. Martin Brenner, John M. Petta, Stephen T. Ross
Life of this patent
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Abstract
The compounds of this invention are substituted benzofurans and benzothiophenes having pharmacological activity. In particular, these compounds have coronary vasodilator activity and are useful in the treatment angina pectoris.
Claims12
A compound of the formula:
- ##SPC6##
- or a pharmaceutically acceptable acid addition salt thereof, in which:
- R.sub.1 is hydrogen, halo, trifluoromethyl, nitro, lower alkyl or lower alkoxy;
- R.sub.2 and R.sub.3 are hydrogen, lower alkyl or lower alkoxy;
- R.sub.4 is hydrogen or straight chain lower alkyl;
- R.sub.5 is straight chain lower alkyl;
- R.sub.6 is phenyl, lower alkylphenyl, di-lower alkylphenyl, tri-lower alkylphenyl, lower alkoxyphenyl, di-lower alkoxyphenyl, tri-lower alkoxyphenyl, halophenyl, dihalophenyl, trihalophenyl, trifluoromethylphenyl, benzyl, halobenzyl, lower alkylbenzyl, lower alkoxybenzyl or trifluoromethylbenzyl;
- n is 2 to 4;
- and
- Z is sulfur.
7 more elements
A compound of the formula:
- ##SPC7##
- or a pharmaceutically acceptable acid addition salt thereof, in which the aminoalkoxy side chain is in the para position of the benzoyl ring;
- R.sub.1 is hydrogen or halo in the 5-position;
- R.sub.2 and R.sub.3 are hydrogen;
- R.sub.4 and R.sub.5 are ethyl, n-propyl or n-butyl;
- R.sub.6 is tolyl, chlorophenyl, bromophenyl, methoxyphenyl, trifluoromethylphenyl, dimethylphenyl, dichlorophenyl, dimethoxyphenyl, trimethoxyphenyl, chlorobenzyl or trifluoromethylbenzyl;
- n is 2 to 4 and Z is oxygen or sulphur.
4 more elements
The compound 2-[4-(3-diethylaminopropoxy)benzoyl]-3-phenylbenzofuran.
The compound 3-[2-(3-diethylaminopropoxy)benzoyl]-2-phenylbenzofuran.
Dependencies are inferred from the claim text.