Salts of phenylpropanolamine with thiazolidine carboxylic acids
AssigneeDeutsche Gold- und Silber-Scheideanstalt vormals Roessler
InventorsFriedrich Asinger, Heribert Offermanns
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Abstract
The d,l-phenylpropanolamine racemate is split with optically active thiazolidine-4-carboxylic acids of the formula: ##EQU1## where R.sub.1 R.sub.2 are hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl, aryl or alkylene of at least 2 carbon atoms or R.sub.1 and R.sub.2 together form a ring of alkyl or alkylene with 4 to 12 carbon atoms and AC is acyl, especially benzoyl, tosyl, nitrophenylsulfenyl, acetyl or preferably formyl.
Claims7
The salt of phenylpropanolamine with a thiazolidine-4-carboxylic acid of the formula ##EQU4## where R.sub.1 and R.sub.2 together are pentamethylene and Ac is benzoyl, tosyl, nitrophenyl sulfenyl, formyl or acetyl.
The salt of an optically active isomer of norephedrine with an optically active form of a thiazolidine carboxylic acid of the formula ##EQU5## where R.sub.1 and R.sub.2 together are pentamethylene and Ac is benzoyl, tosyl, nitrophenylsulfenyl, formyl or acetyl.
Dependencies are inferred from the claim text.