Substituted 4-phenyl isoquinolines
AssigneeHoffman-La Roche Inc.
InventorAlfred Rheiner
Life of this patent
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Abstract
4-Phenyl isoquinolines wherein the 4-phenyl ring is substituted with a halogen or nitro group and processes for their preparation are described. The end products are useful as antidepressant agents.
Claims14
A compound of the formula ##SPC14##
- wherein R signifies hydroxy or lower alkoxy, R.sub.1 signifies hydrogen, R.sub.2 signifies hydrogen, R.sub.3 signifies lower alkyl, R.sub.4 signifies chlorine and o, p and q are the integers 0 or 1, wherein one or two of the characters o, p or q is the integer 0.
The compound wherein q is 0 and p and o are 1, i.e., a compound of the formula 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-2-methyl-7-isoquinolinol.
The compound wherein q is 0 and p and o are 1, i.e., a compound of the formula 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-7-methoxy-2-methylisoquinoline.
The compound wherein R is methoxy, the lower alkyl group as R.sub.3 is ethyl, R.sub.4 is chlorine and q is 0 and p and o are 1, i.e., a compound of the formula 4-(3,4-dichlorophenyl)-2-ethyl-1,2,3,4-tetrahydro-7-methoxyisoquinoline.
The compound wherein R is hydroxy, the lower alkyl group as R.sub.3 is ethyl, R.sub.4 is chlorine and q is 0 and p and o are 1, i.e., a compound of the formula 4-(3,4-dichlorophenyl)-2-ethyl-1,2,3,4-tetrahydro-7-isoquinolinol.
The compound wherein R is methoxy, the lower alkyl group as R.sub.3 is isopropyl, R.sub.4 is chlorine and q is 0 and p and o are 1, i.e., a compound of the formula 4-(3,4-dichlorophenyl)-2-isopropyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin e.
The compound wherein R is hydroxy, the lower alkyl group as R.sub.3 isopropyl, R.sub.4 is chlorine and q is 0 and p and o are 1, i.e., a compound of the formula 4-(3,4-dichlorophenyl)-2-isopropyl-1,2,3,4-tetrahydro-7-isoquinolinol.
Dependencies are inferred from the claim text.