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US 3,947,452 AGranted
2-[(Dihydroisoquinolinyl or dihydroisoindol-2-yl)alkyl]-1H-benz[de]isoquinoline-1,3(2H)-diones
AssigneeE. R. Squibb & Sons, Inc.
InventorsPeter C. Wade, Berthold Richard Vogt
Life of this patent
Estimating the term…
Abstract
Compounds of the following formula and their acid addition salts ##SPC1## Wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from hydrogen, halogen, lower alkyl, lower alkoxy, lower alkylthio, nitro, cyano, amino and trifluoromethyl; A is a straight or branched chain alkylene of 1 to 8 carbons; and m is 1 or 2 are disclosed. These compounds exhibit antidepressant and anti-anxiety activity. In addition these compounds are useful as antiinflammatory agents.
Claims17
A compound of the formula:
- ##SPC14## wherein R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are each independently selected from the group consisting of hydrogen, halogen, lower alkyl of 1 to 4 carabons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, nitro, cyano, amino, and trifluoromethyl;
- A is a straight or branched chain alkylene of 1 to 8 carbons;
- and m is 1 or 2;
- and a pharmaceutically acceptable acid addition salt therof.
1 more element
Dependencies are inferred from the claim text.