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US 3,947,451 AGranted
Derivatives of substituted isoquinoline 1,3-diones
AssigneeAB Kabi
InventorsNils Ake Jonsson, Lembit Mikiver, Pinchas Moses
Life of this patent
Estimating the term…
Abstract
New pharmacodynamically active nitrogen containing heterocyclic compounds of the general formula ##SPC1## As well as methods of preparing the same; and Pharmacodynamical compositions containing the same, preferrably for treating psychiatric and psychosomatic diseases.
Claims22
A compound of the formula ##SPC8##
- in which
- m and n are each one, A is an ethylene or trimethylene group or such a group having a methyl substituent or A signifies an acetyl group or such a group having an .alpha.-alkyl substituent having 1-4 carbon atoms, connected to the group ##EQU4## by the carbonyl CO linkage, R.sup.1 is hydrogen, halogen or a nitro group,
- R.sup.2 and R.sup.3 are saturated normal alkyl groups of up to 6 carbon atoms, or allyl or propargyl or taken together with the carbon atom to which they are bonded form a lower saturated carbocyclic ring, R.sup.4 and R.sup.5 are hydrogen or alkyl groups of at most 6 carbon atoms, or R.sup.4 and R.sup.5 together with the nitrogen form a pyrrolidine or a piperidine ring,
- and, in case A is such an ethylene or trimethylene group, the corresponding amine oxides and quarternary lower alkyl ammonium compounds,
- as well as salts of the basic compounds with non-toxic physiologically acceptable acids.
2 more elements
A compound of the formula ##SPC9##
- in which
- m and n are each one, A is an ethylene or trimethylene group or such a group having a methyl substituent or A signifies an acetyl group or such a group having an .alpha.-alkyl substituent containing 1-4 carbon atoms, connected to the group ##EQU5## by the carbonyl CO linkage, R.sup.1 is hydrogen, halogen or a nitro group,
- R.sup.2 and R.sup.3 are saturated normal alkyl groups of up to 6 carbon atoms, or allyl or propargyl or taken together with the carbon atom to which they are bonded form a lower saturated carbocyclic ring, R.sup.4 and R.sup.5 are hydrogen or alkyl groups of at most 6 carbon atoms,
- and, in case A is such an ethylene or trimethylene group, the corresponding amine oxides and quarternary alkyl ammonium compounds,
- as well as salts of the basic compounds with non-toxic physiologically acceptable acids.
2 more elements
Dependencies are inferred from the claim text.