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US 3,947,445 AGranted
Diazabicyclooctanes and diazabicycloheptanes
AssigneeStanford Research Institute
InventorsDavid W. Henry, Priscilla A. Sturm
Life of this patent
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Abstract
Twelve analogs of diethylcarbamazine as prepared by acylation of 3- and 8-methyl-3,8-diazabicyclo[3.2.1]octane, 2-methyl-2,5-diazabicyclo[2.2.2]octane, and 2-methyl-2,5-diazabicyclo [2.2.1]heptane with diethylcarbamyl chloride, ethyl chloroformate, ethyl isocyanate, and cyclohexanecarbonyl chloride. These compounds are formally derived from diethylcarbamazine in possessing two- or one-carbon bridges over the piperazine ring. The compounds have utility as antifilarial agents and as bronchodilators.
Claims3
A compound having the structure ##SPC3##
- wherein R.sup.4 represents --CON(C.sub.2 H.sub.5).sub.2 or --COOC.sub.2 H.sub.5 ;
- together with the acid addition salts of said compounds.
Dependencies are inferred from the claim text.