Process for producing N.sub.1 -(Dihydroxyalkyl)-5-substituted uracils
OwnerSolomon Aronovich Giller, Regina Abramovna Zhuk +2inventors
InventorsSolomon Aronovich Giller, Regina Abramovna Zhuk, Anna Eduardovna Berzinya, Laima Avgustovna Sherinya
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Abstract
A process for producing N.sub.1 -(dihydroxyalkyl)-5-substituted uracils of the formula: ##SPC1## Wherein R.sub.1 is hydrogen, methyl, a trihalomethyl, a halogen, R.sub.2 is 1,4-dihydroxybutyl-2,1,4-dihydroxypentyl-2,2,5-dihydroxypentyl-1, Characterized by reducing N.sub.1 -(butyrolactone)uracils of the formula: ##SPC2## Wherein R.sub.1 is hydrogen, methyl, a trihalomethyl, a halogen, A is: ##SPC3## With an alkali metal boron hydride in an aqueous or aquo-alcoholic solution at a temperature ranging from 15.degree. to 50.degree.C.
Claims5
A process for producing N.sub.1 -(dihydroxyalkyl)-5-substituted uracils of the formula:
- ##SPC9##
- where R.sub.1 is selected from the group consisting of hydrogen, methyl, trifluoromethyl and fluorine;
- R.sub.2 is selected from the group consisting of 1,4-dihydroxybutyl-2,1,4-dihydroxypentyl-2, and 2,5-dihydroxypentyl-1, comprising reducing N.sub.1 -(butyrolactone) uracils of the formula:
- ##SPC10##
- wherein R.sub.1 is selected from the group consisting of hydrogen, methyl, trifluoromethyl and fluorine;
- and A is selected from the group consisting of ##SPC11##
- with an alkali metal boron hydride in an aqueous or aqua-alcoholic solution at a temperature ranging from 15.degree. to 50.degree.C.
Dependencies are inferred from the claim text.