Process for preparing 1,3-bis(halomethyl)phenobarbitals
AssigneeThe Kendall Company
InventorJulius A. Vida
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Abstract
1,3-Bis(halomethyl)phenobarbitals are prepared by reacting phenobarbital with formaldehyde and a chlorine source or a bromine source at a temperature of -10.degree. to 200.degree.C in the presence of a Lewis acid catalyst, the formaldehyde and bromine or chlorine source being employed in at least approximately twice the molar amounts of phenobarbital. These compounds are useful anticonvulsant agents.
Claims8
A process for preparing 1,3-bis(chloromethyl) phenobarbital or 1,3bis-(bromomethyl) phenobarbital comprising the step of reacting phenobarbital with formaldehyde and a chlorine source or a bromine source selected from the group consisting of hydrochloric acid, hydrobromic acid, and acyl chlorides and bromides selected from the group consisting of acetyl chloride, acetyl bromide, propionyl chloride, butyryl chloride, chloroacetyl chloride, benzoyl chloride, phthaloyl chloride and mixtures of any of the above compounds at a temperature of -10.degree. to 200.degree.C in the presence of a Lewis acid catalyst, the formaldehyde and bromine or chlorine source being employed in at least approximately twice the molar amounts of phenobarbital.
Dependencies are inferred from the claim text.