Back to results
US 3,947,441 AGranted
Substituted 2-amino-4-(hydroxyamino)-pyrimidines
AssigneeCiba-Geigy Corporation
InventorsErnst Schweizer, Jorg Frei, Atso Ilvespaa
Life of this patent
Estimating the term…
Abstract
Cpmpounds of the class of 5-substituted and 5,6-disubstituted 2-amino-4-(hydroxyamino) and 2,4-bis-(hydroxyamino)pyrimidines and their pharmaceutically acceptable acid addition salts possess valuable biological properties, in particular antibacterial and antimalarial activity and potentiate the action of antibacterial sulphanilamide derivatives. Specific embodiments are 2-amino-4-(hydroxyamino)-5-(3,4,5-trimethoxybenzyl)-pyrimidine, and 2-amino-4-(hydroxyamino)-5-(p-chlorophenyl)-6-ethyl pyrimidine and its hydrochloride.
Claims8
A pyrimidine of the formula I ##SPC3##
- wherein
- R.sub.1 represents hydroxy, benzyloxy or tetrahydropyran-2-yloxy,
- R.sub.2 represents amino or,
- R.sub.3 represents phenyl, benzyl, phenyl or benzyl which are mono-or trisubstituted by a member selected from the group consisting of chlorine and methoxy,
- R.sub.4 represents hydrogen, methyl, or ethyl and their pharmaceutically acceptable addition salts with inorganic and organic acids.
2 more elements
Dependencies are inferred from the claim text.