Manufacture of 2-(alkyl)amino-4-hydroxy-5-alkylpyrimidines
AssigneeImperial Chemical Industries PLC
InventorsAlbert Edward Kaye, Alan Cyril Tucker
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Abstract
Reaction of a 2-amino-, 2-alkylamino- or 2-dialkylamino-4-hydroxypyrimidine, preferably also containing a methyl group at the 6 position, with an aldehyde R--CHO in presence of hydrogen and a hydrogenation catalyst introduces an alkyl group R--CH.sub.2 -- into the 5 position. The reaction is preferably carried out under superatmospheric pressure at a temperature between 80.degree. and 180.degree.C and is aided by metal salts, acids, amines, amine salts or basic ion-exchange resins.
Claims8
A process for the manufacture of 2-amino-2-alkylamino- or 2-dialkylamino-4-hydroxy-5-alkylpyrimidines comprising the step of reacting 2-amino-, 2-alkylamino- or 2-dialkylamino-4-hydroxy-pyrimidine wherein the alkyl group or groups on the 2-amino group have not more than six carbon atoms with an aldehyde of the formula R.CHO wherein R is a hydrogen atom, alkyl having not more than five carbon atoms, alkenyl of 2 to 4 carbon atoms or phenyl in presence of hydrogen and a supported palladium hydrogenation cataylst.
Dependencies are inferred from the claim text.