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US 3,947,438 AGranted
Decarbonylation of quinoxalines
AssigneePfizer Inc.
InventorRobert F. Myers
Life of this patent
Estimating the term…
Abstract
Designated 2-formylquinoxaline 1,4-dioxides are decarbonylated by the action of an unhindered secondary amine having a pK.sub.a greater than about 8 to produce the corresponding decarbonylated product.
Claims6
A process which comprises subjecting an aldehyde having the formula ##SPC2##
- where
- R is in either of the indicated positions and is hydrogen, alkyl, having up to four carbons, alkoxy having up to four carbons, alkylthio having up to four carbons, alkylsulfinyl having up to four carbons, alkylsulfonyl having up to four carbons, fluoro, chloro, bromo, cyano, trifluoromethyl, alkanoyl having two to four carbons, CONR.sup.1 R.sup.2 or SO.sub.2 NR.sup.1 R.sup.2, R.sup.1 and R.sup.2 being separately selected from the class consisting of hydrogen and alkyl having up to three carbons,
- in liquid condition to the action of at least 0.5 molar equivalents of an unhindered secondary amine having a pK.sub.a greater than about 8, at a temperature of from about 30.degree. to about 150.degree.C., to decarbonylate the CHO group and form the corresponding decarbonylated product.
Dependencies are inferred from the claim text.