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US 3,946,119 AGranted
Optionally substituted .alpha.-tertiary butyl-p-phenoxybenzylamines and their use as hypolipidemic agents
AssigneeSandoz Ltd.
InventorFaizulla G. Kathawala
Life of this patent
Estimating the term…
Abstract
Hypolipidemic agents of the formula: ##SPC1## Wherein R is hydrogen, alkyl or halo, R' and R" are hydrogen, halo, alkyl or alkoxy, R'" is alkyl, and n is 1 or 2.
Claims19
A compound of the formula:
- ##SPC8##
- wherein
- R is hydrogen, alkyl of 1 to 4 carbon atoms, or halo of atomic weight of from 18 to 36,
- R' and R" are independently hydrogen, halo of atomic weight of from 18 to 36, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms,
- R'" is alkyl of 1 to 5 carbon atoms, and
- n is 1 or 2,
- or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
A pharmaceutical composition in unit dosage form for treating lipidemia in mammals comprising an inert pharmaceutically acceptable carrier and from 75 to 1500 milligrams of a compound of the formula:
- ##SPC11##
- wherein
- R is hydrogen, alkyl of 1 to 4 carbon atoms, or halo of atomic weight of from 18 to 36,
- R' and R" are independently hydrogen, halo of atomic weight of from 18 to 36, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms,
- R'" is alkyl of 1 to 5 carbon atoms, and
- n is 1 or 2,
- or a pharmaceutically accpetable acid addition salt thereof.
4 more elements
The method for treating a mammal having lipidemia comprising administering a hypolipidemic effective amount to said mammal of a compound of the formula:
- ##SPC14##
- wherein
- R is hydrogen, alkyl of 1 to 4 carbon atoms, or halo of atomic weight of from 18 to 36,
- R' and R" are independently hydrogen, halo of atomic weight of from 18 to 36, alkyl of 1 to 4 carbon atoms, or alkoxy of 1 to 4 carbon atoms,
- R'" is alkyl of 1 to 5 carbon atoms, and
- n is 1 or 2,
- or a pharmaceutically acceptable acid addition salt thereof.
4 more elements
Dependencies are inferred from the claim text.