Pharmaceutically useful bis-basic ester and thioester derivatives
AssigneeRichardson-Merrell Inc.
InventorIrving Shemano
Life of this patent
Estimating the term…
Abstract
Bis-basic ester derivatives of the following general formula are useful in the treatment of conditions of delayed hypersensitivity. ##EQU1## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, fluoren-9-one, carbazole, or N-(lower)alkyl carbazole; X represents oxygen or sulfur; A represents a straight or branched alkylene chain of from 2 to 6 carbon atoms; and each of R.sup.1 and R.sup.2 is hydrogen, straight or branched lower alkyl of from 1 to 4 carbon atoms, or alkenyl of from 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position; and pharmaceutically useful acid addition salts thereof.
Claims9
A method of treating conditions of delayed hypersensitivity which comprises administering to a patient in need thereof a compound selected from the formula ##EQU7## wherein [W] represents an aromatic polycyclic nucleus selected from fluoranthene, fluorene, fluoren-9-ol, or fluoren-9-one X is selected from oxygen or sulfur;
- A is selected from a straight or branched alkylene chain of from 2 to 6 carbon atoms;
- and each of R.sup.1 and R.sup.2 is selected from hydrogen, straight or branched lower alkyl of from 1 to 4 carbon atoms or alkenyl of 3 to 6 carbon atoms having the vinyl unsaturation in other than the 1-position;
- and pharmaceutically acceptable acid addition salts thereof, in an amount effective to suppress delayed hypersensitivity.
Dependencies are inferred from the claim text.