19-Norpregna- 1,3,5(10)-trien-3-ol and loweralkyl homologs thereof having postcoital antifertility activity
AssigneeStanford Research Institute
InventorsDavid F. Crowe, Richard H. Peters, Masato Tanabe, George Detre
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Abstract
19-Norpregna-1,3,5(10)-trien-3-ol and loweralkyl homologs thereof wherein the alkyl group attached in the 17.beta. position contains from 2 to 7 carbon atoms. Said compounds, along with the corresponding known 17.beta.-methyl derivative, are found to have antifertility activity, and particularly postcoital antifertility activity, along with very low estrogenic activity, when administered orally to mammals.
Claims6
A compound having the structure ##SPC4##
- wherein R.sup.1 represents a straight or branched loweralkyl group of from 2 to 7 carbon atoms.
A method of preventing pregnancy in mammals which comprises postcoitally administering to said mammals an effective amount of a compound of the structure ##SPC5##
- wherein R.sup.1 represents a straight or branched loweralkyl group of from 2 to 7 carbon atoms.
A method of preventing pregnancy in mammals which comprises postcoitally administering to said mammals an effective amount of 17.beta.-methyl-estra-1,3,5,(10)-trien-3-ol.
Dependencies are inferred from the claim text.