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US 3,946,035 AGranted
Anti-inflammatory polymers, pharmaceutical compositions containing the same and process for producing said polymers
AssigneeL'oreal
InventorsBernard Jacquet, Christos Papantoniou, Pierre Dufaure, Claude Mahieux
Life of this patent
Estimating the term…
Abstract
A polymer has on its macromolecular chains in the form of a lateral branching an anti-inflammator residue having a carboxylic acid function chemically linked to the macromolecular chains by an intermediate covalent function.
Claims13
A polymeric compound containing repeating units of the formula ##EQU12## wherein R.sup.1 and R.sup.2 are selected from the group of values consisting of
- a. R.sub.2 is --[O--CO--CH.sub.2 ]n --o --Z,
- R.sup.1 is hydrogen and n is 1-10,
- b. R.sub.2 is --CH.sub.2 --O--CO--CH.sub.2 -- 0 --Z and R.sup.1 is hydrogen or methyl,
- c. R.sub.2 is --CH.sub.2 --NH--CO--CH.sub.2 --O--Z and R.sup.1 is hydrogen,
- d. R.sub.2 is --CO--NH--CH.sub.2 --NH--CO--CH.sub.2 --O--Z and R.sup.1 is hydrogen, and ##EQU13## wherein r and r' represent alkyl having 1-3 carbon atoms, Y represents chlorine or bromine and R.sup.1 is hydrogen or methyl, and Z is the acyl residue of an anti-inflammatory carboxylic pharmaceutical agent selected from the group consisting of ##SPC26##
- wherein X.sub.1 represents Cl, Br, F or I and said alkyl has 1-3 carbon atoms, ##SPC27##
- wherein Z.sub.1 is selected from the group consisting of hydrogen and methyl, and X.sub.2 is selected from the group consisting of hydrogen and methoxy, ##SPC28##
4 more elements
A polymeric compound containing repeating units of the formula ##EQU17## wherein R.sup.1 and R.sub.2 are selected from the group of values consisting of:
- a. R.sub.2 is [ O--CO--CH.sub.2 ]--O- Z, R.sup.1 is hydrogen and n is 1-10,
- b. R.sub.2 is --CH.sub.2 --O--CO--CH.sub.2 --O-- Z and R.sub.1 is hydrogen or methyl,
- c. R.sub.2 is --CH.sub.2 --NH--CO--CH.sub.2 --O-- Z and R.sup.1 is hydrogen,
- d. R.sub.2 is --CO--NH--CH.sub.2 --NH--CO--CH.sub.2 --O-- Z and R.sup.1 is hydrogen, and ##EQU18## r and r' represent alkyl having 1-3 carbon atoms, Y represents chlorine or bromine, and R.sup.1 is hydrogen or methyl, and wherein Z is the acyl residue of an anti-inflammatory pharmaceutical agent whose molecule comprises a carboxylic acid function.
1 more element
Dependencies are inferred from the claim text.