Acetal derivatives of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde
AssigneeCiba-Geigy Corporation
InventorsHans Allgeier, Andre Gagneux
Life of this patent
Estimating the term…
Abstract
Compounds of the class of acetals of 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde and the 5-oxides and pharmaceutically acceptable acid addition salts thereof have valuable pharmacological properties, in particular anticonvulsant effectiveness. Further, they show central depressant and muscle-relaxing activity and are active ingredients for therapeutic preparations. Specific embodiments are 6-phenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carboxaldehyde -diethylacetal, 6-(o-chlorophenyl)-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carb oxaldehyde-diethylacetal and 6-(o-fluorophenyl-8-chloro-4H-s-triazolo[4,3-a][1,4]benzodiazepine-1-carbo xaldehyde-diethylacetal.
Claims11
A compound having the formula I a, ##SPC6##
- wherein
- R.sub.1 represents a hydrogen atom or a methyl or ethyl group,
- each of the symbols R.sub.2 represents a methyl or ethyl group, and
- R.sub.3 and R.sub.4, independently of each other, represents hydrogen, a chlorine, fluorine or bromine atom, or a nitro or trifluoromethyl group, at least one of the symbols R.sub.3 and R.sub.4 being other than hydrogen,
- as well as the 5-oxide thereof.
Dependencies are inferred from the claim text.