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US 3,946,027 AGranted
3,5,6-Tricarboxy-4-pyridyl-1,4-dihydropyridine derivatives
AssigneeBayer Aktiengesellschaft
InventorsFriedrich Bossert, Horst Meyer, Wulf Vater
Life of this patent
Estimating the term…
Abstract
1,4-Dihydropyridines bearing carboxy functions in the 3-, 5- and 6- or 2-, 3-, 5- and 6-positions and being substituted in the 4-position by phenyl, substituted phenyl, naphthyl, phenylalkyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5,6-tricarboxylic acid triethylester is a representative embodiment, are prepared through condensation of an enamine with an ylidene acid ester, the latter being separately prepared or prepared in situ.
Claims8
A compound of the formula:
- ##SPC52##
- or a pharmaceutically acceptable non-toxic salt thereof, wherein
- R is hydrogen, alkyl of up to 4 carbon atoms or alkenyl of up to 4 carbon atoms;
- R.sup.1 is hydrogen or alkyl of up to 4 carbon atoms;
- each of R.sup.2 and R.sup.3, taken independently of the other, is alkyl of up to 4 carbon atoms, hydroxy alkyl of up to 4 carbon atoms, alkoxy alkyl of up to 4 carbon atoms, alkenyl of up to 4 carbon atoms or alkynyl of up to 4 carbon atoms;
- R.sup.5 is hydrogen or alkyl of up to 4 carbon atoms;
- and
- X is pyridyl unsubstituted or substituted by one or two members selected from the group consisting of alkyl of up to 4 carbon atoms, alkoxy of up to 4 carbon atoms, and halogeno;
- and
- n has a value of 0 to 3.
7 more elements
Dependencies are inferred from the claim text.